Title : Investigation of the predictive validity of laser-EPs in normal, UVB-inflamed and capsaicin-irritated skin with four analgesic compounds in healthy volunteers.

Pub. Date : 2017 Jul

PMID : 28139023






2 Functional Relationships(s)
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1 RESULTS: In normal skin, the averaged postdose LEP peak-to-peak-(PtP)-amplitudes were reduced by pregabalin (-2.68 muV; 95% confidence interval (CI) -4.16, 1.19) and duloxetine (-1.73 muV; 95% CI -3.21, -0.26) but not by lacosamide and celecoxib vs. placebo. Lacosamide leptin Homo sapiens
2 LEP PtP amplitudes on capsaicin-irritated skin, reflecting peripheral/spinal sensitization, as in neuropathic pain, were reduced by pregabalin (-3.78 muV; 95% CI -5.31, -2.25) and duloxetine (-2.32 muV; 95% CI -3.82, -0.82) but not by celecoxib or lacosamide vs. placebo, which was in agreement with known clinical profiles. Lacosamide leptin Homo sapiens