Title : 5-ASA-loaded SiO2 nanoparticles-a novel drug delivery system targeting therapy on ulcerative colitis in mice.

Pub. Date : 2017 Mar

PMID : 28138699






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1 The therapeutic effect of 5-ASA-SiO2 NPs was assessed based on their disease activity index (DAI), colon histopathology, myeloperoxidase (MPO) and levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6). Mesalamine interleukin 6 Mus musculus
2 The therapeutic effect of 5-ASA-SiO2 NPs was assessed based on their disease activity index (DAI), colon histopathology, myeloperoxidase (MPO) and levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6). Mesalamine interleukin 6 Mus musculus
3 Expression of IL-6 and TNF-alpha mRNA in colonic mucosa in the normal dosage, high dosage and 5-ASA-SiO2 NP group was significantly lower than that in the model group. Mesalamine interleukin 6 Mus musculus
4 Colonic mucosal IL-6 and TNF-alpha mRNA expression in the high dosage and 5-ASA-SiO2 NP groups was significantly lower than that in the normal dosage group (P<0.05). Mesalamine interleukin 6 Mus musculus