Title : Investigation of the Regulatory Effects of Saccharin on Cytochrome P450s in Male ICR Mice.

Pub. Date : 2017 Jan

PMID : 28133510






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1 Here, we examined the effects of the potential saccharin-drug interaction on the activities of 5 cytochrome P450 (CYPs) in male ICR mice; further, we examined the effects of saccharin (4,000 mg/kg) on the pharmacokinetics of bupropion after pretreatment of mice with saccharin for 7 days and after concomitant administration of bupropion and saccharin. Saccharin cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus