Pub. Date : 2017 Mar
PMID : 28131902
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CQ synergistically sensitizes human colorectal cancer cells to SN-38/CPT-11 through lysosomal and mitochondrial apoptotic pathway via p53-ROS cross-talk. | Irinotecan | tumor protein p53 | Homo sapiens |
| 2 | CQ synergistically sensitizes human colorectal cancer cells to SN-38/CPT-11 through lysosomal and mitochondrial apoptotic pathway via p53-ROS cross-talk. | Irinotecan | tumor protein p53 | Homo sapiens |
| 3 | Notably, another autophagy inhibitor chloroquine (CQ) synergistically enhanced the anti-tumor activity of SN-38 in CRC cells with wild type (WT) p53. | Irinotecan | tumor protein p53 | Homo sapiens |
| 4 | Subsequently, we identified a potential mechanism of this cooperative interaction by showing that CQ and SN-38 acted together to trigger reactive oxygen species (ROS) burst, upregulate p53 expression, elicit the loss of lysosomal membrane potential (LMP) and mitochondrial membrane potential ( psim). | Irinotecan | tumor protein p53 | Homo sapiens |
| 5 | In addition, ROS induced by CQ plus SN-38 upregulated p53 levels by activating p38, conversely, p53 stimulated ROS. | Irinotecan | tumor protein p53 | Homo sapiens |
| 6 | Altogether, all results suggested that CQ synergistically sensitized human CRC cells with WT p53 to SN-38 through lysosomal and mitochondrial apoptotic pathway via p53-ROS cross-talk. | Irinotecan | tumor protein p53 | Homo sapiens |