Pub. Date : 2017 Mar
PMID : 28131902
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | In addition, ROS induced by CQ plus SN-38 upregulated p53 levels by activating p38, conversely, p53 stimulated ROS. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
2 | In addition, ROS induced by CQ plus SN-38 upregulated p53 levels by activating p38, conversely, p53 stimulated ROS. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
3 | Altogether, all results suggested that CQ synergistically sensitized human CRC cells with WT p53 to SN-38 through lysosomal and mitochondrial apoptotic pathway via p53-ROS cross-talk. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |