Title : CQ synergistically sensitizes human colorectal cancer cells to SN-38/CPT-11 through lysosomal and mitochondrial apoptotic pathway via p53-ROS cross-talk.

Pub. Date : 2017 Mar

PMID : 28131902






3 Functional Relationships(s)
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Protein Name
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1 In addition, ROS induced by CQ plus SN-38 upregulated p53 levels by activating p38, conversely, p53 stimulated ROS. Reactive Oxygen Species tumor protein p53 Homo sapiens
2 In addition, ROS induced by CQ plus SN-38 upregulated p53 levels by activating p38, conversely, p53 stimulated ROS. Reactive Oxygen Species tumor protein p53 Homo sapiens
3 Altogether, all results suggested that CQ synergistically sensitized human CRC cells with WT p53 to SN-38 through lysosomal and mitochondrial apoptotic pathway via p53-ROS cross-talk. Reactive Oxygen Species tumor protein p53 Homo sapiens