Pub. Date : 2017 Jun
PMID : 28130615
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Age-dependent changes of cerebral copper metabolism in Atp7b -/- knockout mouse model of Wilson"s disease by [64Cu]CuCl2-PET/CT. | cupric chloride | ATPase, Cu++ transporting, beta polypeptide | Mus musculus |
| 2 | The objective of this study was to explore the feasibility and use of copper-64 chloride ([64C]CuCl2) as a tracer for noninvasive assessment of age-dependent changes of cerebral copper metabolism in WD using an Atp7b -/- knockout mouse model of WD and positron emission tomography/computed tomography (PET/CT) imaging. | cupric chloride | ATPase, Cu++ transporting, beta polypeptide | Mus musculus |
| 3 | Continuing from our recent study of biodistribution and radiation dosimetry of [64C]CuCl2 in Atp7b -/- knockout mice, PET quantitative analysis revealed low 64Cu radioactivity in the brains of Atp7b -/- knockout mice at 7th weeks of age, compared with 64Cu radioactivity in the brains of age- and gender-matched wild type C57BL/6 mice, at 24 h (h) post intravenous injection of [64C]CuCl2 as a tracer. | cupric chloride | ATPase, Cu++ transporting, beta polypeptide | Mus musculus |
| 4 | Furthermore, age-dependent increase of 64Cu radioactivity was detected in the brains of Atp7b -/- knockout mice from the 13th to 21th weeks of age, based on the data derived from a longitudinal [64C]CuCl2-PET/CT study of Atp7b -/- knockout mice with orally administered [64Cu]CuCl2 as a tracer. | cupric chloride | ATPase, Cu++ transporting, beta polypeptide | Mus musculus |
| 5 | Furthermore, age-dependent increase of 64Cu radioactivity was detected in the brains of Atp7b -/- knockout mice from the 13th to 21th weeks of age, based on the data derived from a longitudinal [64C]CuCl2-PET/CT study of Atp7b -/- knockout mice with orally administered [64Cu]CuCl2 as a tracer. | cupric chloride | ATPase, Cu++ transporting, beta polypeptide | Mus musculus |