Title : Inhalable bioresponsive chitosan microspheres of doxorubicin and soluble curcumin augmented drug delivery in lung cancer cells.

Pub. Date : 2017 May

PMID : 28130133






4 Functional Relationships(s)
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1 In present investigation, doxorubicin (Dox) and soluble curcumin (Cur-2-HP-beta-CD-complex) combination was simultaneously loaded in inhalable bioresponsive chitosan microspheres (Dox/Cur-2-HP-beta-CD-complex-elastin-CMs) bearing a substrate-stimuli, elastin. Doxorubicin elastin Homo sapiens
2 In present investigation, doxorubicin (Dox) and soluble curcumin (Cur-2-HP-beta-CD-complex) combination was simultaneously loaded in inhalable bioresponsive chitosan microspheres (Dox/Cur-2-HP-beta-CD-complex-elastin-CMs) bearing a substrate-stimuli, elastin. Doxorubicin elastin Homo sapiens
3 Consistently, inhalable bioresponsive microspheres exhibited outstandingly lower IC50 of 3.4-muM in comparison to 6.5-muM of inhalable drug loaded microspheres (Dox/Cur-2-HP-beta-CD-complex-CMs) bearing no elastin, against A549, non-small cell lung cancer cells. Doxorubicin elastin Homo sapiens
4 In conclusion, Dox/Cur-2-HP-beta-CD-complex-elastin-CMs warrant further in-vivo tumor regression study to prove its therapeutic efficacy. Doxorubicin elastin Homo sapiens