Pub. Date : 2017 Jan
PMID : 28123585
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Host knockout of E-prostanoid 2 receptors reduces tumor growth and causes major alterations of gene expression in prostaglandin E2-producing tumors. | Dinoprostone | prostaglandin E receptor 2 (subtype EP2) | Mus musculus |
| 2 | EP2-knockout mice were bred and implanted with EP2 receptor-expressing and PGE2-producing epithelial-like tumors. | Dinoprostone | prostaglandin E receptor 2 (subtype EP2) | Mus musculus |
| 3 | Overall, PGE2 signaling via host EP2 receptors affected a large number of different genes involved in tumor progression based on signaling between host stroma and tumor cells, which caused reduced tumor growth. | Dinoprostone | prostaglandin E receptor 2 (subtype EP2) | Mus musculus |