Title : Beta-agonist stimulation ameliorates the phenotype of spinal and bulbar muscular atrophy mice and patient-derived myotubes.

Pub. Date : 2017 Jan 24

PMID : 28117338






3 Functional Relationships(s)
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Protein Name
Organism
1 Expression of polyglutamine-expanded AR causes damage to motor neurons and skeletal muscle cells. polyglutamine androgen receptor Mus musculus
2 We show that treatment of myotubes expressing polyglutamine-expanded AR with the beta-agonist clenbuterol increases their size. polyglutamine androgen receptor Mus musculus
3 Clenbuterol activated the phosphatidylinositol-3-kinase (PI3K)/Akt/mechanistic target of rapamycin (mTOR) pathway and decreased the accumulation of polyglutamine-expanded AR. polyglutamine androgen receptor Mus musculus