Title : Myeloperoxidase targets oxidative host attacks to Salmonella and prevents collateral tissue damage.

Pub. Date : 2017 Jan 23

PMID : 28112722






2 Functional Relationships(s)
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1 A computational model predicted that myeloperoxidase efficiently scavenges diffusible H2O2 at the surface of phagosomal Salmonella and converts it into highly reactive HOCl (bleach), which rapidly damages biomolecules within a radius of less than 0.1 mum. Hypochlorous Acid myeloperoxidase Homo sapiens
2 These data show that myeloperoxidase has a major function in mitigating collateral tissue damage during antimicrobial oxidative bursts, by converting diffusible long-lived H2O2 into highly reactive, microbicidal and locally confined HOCl at pathogen surfaces. Hypochlorous Acid myeloperoxidase Homo sapiens