Title : Computational analysis of Amsacrine resistance in human topoisomerase II alpha mutants (R487K and E571K) using homology modeling, docking and all-atom molecular dynamics simulation in explicit solvent.

Pub. Date : 2017 Mar

PMID : 28110185






1 Functional Relationships(s)
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1 In this study, we constructed human topoisomerase II alpha (hTop2alpha) homology model docked with Amsacrine based on crystal structure of human Top2beta in complex with etoposide. Etoposide DNA topoisomerase II alpha Homo sapiens