Pub. Date : 2017 Aug 7
PMID : 28109089
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Betulinic Acid Inhibits Cell Proliferation in Human Oral Squamous Cell Carcinoma via Modulating ROS-Regulated p53 Signaling. | betulinic acid | tumor protein p53 | Homo sapiens |
| 2 | BA dose-dependently increased p53 expression in KB cells and implanted tumors. | betulinic acid | tumor protein p53 | Homo sapiens |
| 3 | Knockdown of p53 blocked BA-induced increase in apoptosis, cell cycle arrest, and inhibition of cell proliferation. | betulinic acid | tumor protein p53 | Homo sapiens |
| 4 | NAC treatment suppressed BA-induced increase in p53 expression. | betulinic acid | tumor protein p53 | Homo sapiens |
| 5 | Taken together, the data demonstrated that ROS-p53 signaling was crucial for BA-exhibited antitumor effect in OSCC. | betulinic acid | tumor protein p53 | Homo sapiens |