Pub. Date : 2017 Aug 7
PMID : 28109082
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | To confirm that ERBB2 is a direct target of miR-133a, a luciferase reporter assay was performed. | mir-133a | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 2 | ERBB2 was a direct target of miR-133a, and it was negatively regulated by miR-133a. | mir-133a | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 3 | Interestingly, ERBB2 silencing has a similar impact to miR-133a overexpression, in that it significantly induced apoptosis and inhibited ERK and AKT activation. | mir-133a | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 4 | Our study showed that miR-133a inhibits the proliferation of gastric cancer cells by downregulating the expression of ERBB2 and its downstream signaling molecules p-ERK1/2 and p-AKT. | mir-133a | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |