Title : Curcumin suppresses the proliferation of gastric cancer cells by downregulating H19.

Pub. Date : 2016 Dec

PMID : 28105222






3 Functional Relationships(s)
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1 Curcumin, a major phytochemical in turmeric, inhibits the proliferation of many types of solid cancer cells by enhancing p53 expression. Curcumin tumor protein p53 Homo sapiens
2 The protein expression of p53, B-cell lymphoma (Bcl)-2, Bcl-2-associated X protein (Bax) and c-Myc in curcumin-treated cells was detected by western blotting. Curcumin tumor protein p53 Homo sapiens
3 Furthermore, while curcumin induced cell apoptosis and enhanced the expression ratio of Bax/Bcl-2, which are downstream molecules of p53, ectopic expression of H19 inhibited curcumin-induced cell apoptosis. Curcumin tumor protein p53 Homo sapiens