Title : Simultaneous Targeting of NPC1 and VDAC1 by Itraconazole Leads to Synergistic Inhibition of mTOR Signaling and Angiogenesis.

Pub. Date : 2017 Jan 20

PMID : 28103683






1 Functional Relationships(s)
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1 We further map the binding site of itraconazole to the sterol-sensing domain of NPC1 using mutagenesis, competition with U18666A, and molecular docking. Sterols NPC intracellular cholesterol transporter 1 Homo sapiens