Pub. Date : 2017 Jan 20
PMID : 28103683
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Simultaneous Targeting of NPC1 and VDAC1 by Itraconazole Leads to Synergistic Inhibition of mTOR Signaling and Angiogenesis. | Itraconazole | NPC intracellular cholesterol transporter 1 | Homo sapiens |
| 2 | In this study, we demonstrate that cholesterol trafficking inhibition by itraconazole is due to direct inhibition of the lysosomal protein NPC1. | Itraconazole | NPC intracellular cholesterol transporter 1 | Homo sapiens |
| 3 | We further map the binding site of itraconazole to the sterol-sensing domain of NPC1 using mutagenesis, competition with U18666A, and molecular docking. | Itraconazole | NPC intracellular cholesterol transporter 1 | Homo sapiens |