Title : Effects of obesity and exercise on testicular leptin signal transduction and testosterone biosynthesis in male mice.

Pub. Date : 2017 Apr 1

PMID : 28100475






1 Functional Relationships(s)
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1 The results showed that a high-fat diet causes obesity, leptin resistance, inhibition of the testicular LEP-JAK-STAT pathway, decreased mRNA and protein expression of steroidogenic factor-1, steroidogenic acute regulatory protein, and the P-450 side-chain cleavage enzyme, a decrease in the serum testosterone-to-estradiol ratio, and declines in sperm quality parameters. Testosterone nuclear receptor subfamily 5, group A, member 1 Mus musculus