Pub. Date : 2017 Mar
PMID : 28090646
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Influence of P-glycoprotein on the disposition of fexofenadine and its enantiomers. | fexofenadine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | Using fexofenadine as a model compound, we developed and validated HPLC-fluorescence methods to determine the effect of P-gp on the disposition of fexofenadine and its enantiomers. | fexofenadine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | Using fexofenadine as a model compound, we developed and validated HPLC-fluorescence methods to determine the effect of P-gp on the disposition of fexofenadine and its enantiomers. | fexofenadine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | KEY FINDINGS: This study demonstrates that P-gp prefers to transport (S)-fexofenadine, and P-gp deficiency causes the increase in both (R)-fexofenadine and (S)-fexofenadine in plasma. | fexofenadine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 5 | KEY FINDINGS: This study demonstrates that P-gp prefers to transport (S)-fexofenadine, and P-gp deficiency causes the increase in both (R)-fexofenadine and (S)-fexofenadine in plasma. | fexofenadine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 6 | Racemic fexofenadine, (R)-fexofenadine and (S)-fexofenadine were increased in ABCB1-1Delta Collies (118.7, 72.0 and 48.3 ng/ml) compared to wild-type Collies (25.0, 16.5 and 7.7 ng/ml) at 1 h postadministration. | fexofenadine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 7 | Racemic fexofenadine, (R)-fexofenadine and (S)-fexofenadine were increased in ABCB1-1Delta Collies (118.7, 72.0 and 48.3 ng/ml) compared to wild-type Collies (25.0, 16.5 and 7.7 ng/ml) at 1 h postadministration. | fexofenadine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 8 | The results demonstrate that the stereoselectivity of P-gp plays a key role in the disposition of fexofenadine enantiomers. | fexofenadine | ATP binding cassette subfamily B member 1 | Homo sapiens |