Title : Carnosic Acid Suppresses the H2O2-Induced Mitochondria-Related Bioenergetics Disturbances and Redox Impairment in SH-SY5Y Cells: Role for Nrf2.

Pub. Date : 2018 Feb

PMID : 28084591






2 Functional Relationships(s)
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1 In the present work, we found that a pretreatment of human neuroblastoma SH-SY5Y cells with CA at 1 muM for 12 h prevented the hydrogen peroxide (H2O2)-induced impairment of the TCA enzymes (aconitase, alpha-ketoglutarate dehydrogenase (alpha-KGDH), succinate dehydrogenase (SDH)) and abolished the inhibition of the complexes I and V and restored the levels of ATP by a mechanism associated with Nrf2. Hydrogen Peroxide succinate dehydrogenase complex iron sulfur subunit B Homo sapiens
2 In the present work, we found that a pretreatment of human neuroblastoma SH-SY5Y cells with CA at 1 muM for 12 h prevented the hydrogen peroxide (H2O2)-induced impairment of the TCA enzymes (aconitase, alpha-ketoglutarate dehydrogenase (alpha-KGDH), succinate dehydrogenase (SDH)) and abolished the inhibition of the complexes I and V and restored the levels of ATP by a mechanism associated with Nrf2. Hydrogen Peroxide succinate dehydrogenase complex iron sulfur subunit B Homo sapiens