Pub. Date : 1989 Nov 15
PMID : 2808430
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Activation of the second promoter of the transforming growth factor-beta 1 gene by transforming growth factor-beta 1 and phorbol ester occurs through the same target sequences. | Phorbol Esters | transforming growth factor beta 1 | Homo sapiens |
| 2 | Two distinct regions of the transforming growth factor-beta 1 (TGF-beta 1) promoter are responsive to autoregulation and activation by phorbol ester (12-O-tetradecanoylphorbol-13-acetate): sequences located between nucleotides -454 to -323 (first promoter) and between the two transcriptional start sites. | Phorbol Esters | transforming growth factor beta 1 | Homo sapiens |
| 3 | Two distinct regions of the transforming growth factor-beta 1 (TGF-beta 1) promoter are responsive to autoregulation and activation by phorbol ester (12-O-tetradecanoylphorbol-13-acetate): sequences located between nucleotides -454 to -323 (first promoter) and between the two transcriptional start sites. | Phorbol Esters | transforming growth factor beta 1 | Homo sapiens |
| 4 | We have now characterized in detail the induction of the second promoter (sequences between nucleotides + 1 to +271) of the TGF-beta 1 gene by both TGF-beta 1 and phorbol ester. | Phorbol Esters | transforming growth factor beta 1 | Homo sapiens |
| 5 | These results suggest that AP-1, which is capable of conferring phorbol ester or TGF-beta 1 responsiveness, is the major transcription factor involved in the second promoter-derived transcription of the TGF-beta 1 gene. | Phorbol Esters | transforming growth factor beta 1 | Homo sapiens |