Title : Carnosic Acid Induces Anti-Inflammatory Effects in Paraquat-Treated SH-SY5Y Cells Through a Mechanism Involving a Crosstalk Between the Nrf2/HO-1 Axis and NF-κB.

Pub. Date : 2018 Jan

PMID : 28083817






2 Functional Relationships(s)
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1 Carnosic Acid Induces Anti-Inflammatory Effects in Paraquat-Treated SH-SY5Y Cells Through a Mechanism Involving a Crosstalk Between the Nrf2/HO-1 Axis and NF-kappaB. Paraquat NFE2 like bZIP transcription factor 2 Homo sapiens
2 SH-SY5Y cells were pretreated for 12 h with CA at 1 muM before exposure to PQ for further 24 h. CA suppressed the PQ-induced alterations on the levels of interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and cyclooxygenase-2 (COX-2) through a mechanism involving the activation of the Nrf2/HO-1 axis. Paraquat NFE2 like bZIP transcription factor 2 Homo sapiens