Title : Discovery of new nanomolar inhibitors of GPa: Extension of 2-oxo-1,2-dihydropyridinyl-3-yl amide-based GPa inhibitors.

Pub. Date : 2017 Feb 15

PMID : 28076824






1 Functional Relationships(s)
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1 The SAR revealed the minor influence of the amide group, importance of the pyridone ring both spatially around the pyridine ring and for possible pi-stacking, and confirmed a preference for inclusion of 3,4-dichlorobenzyl moieties, as bookends to the pyridone scaffold. Pyridones sarcosine dehydrogenase Homo sapiens