Title : DNA fragile site breakage as a measure of chemical exposure and predictor of individual susceptibility to form oncogenic rearrangements.

Pub. Date : 2017 Mar 1

PMID : 28069693






1 Functional Relationships(s)
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1 Here, we demonstrate that treatment with non-cytotoxic levels of environmental chemicals (benzene and diethylnitrosamine) or chemotherapeutic agents (etoposide and doxorubicin) generates significant DNA breakage within RET at levels similar to those generated by fragile site-inducing laboratory chemicals. Diethylnitrosamine ret proto-oncogene Homo sapiens