Pub. Date : 1989 Nov
PMID : 2806411
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Tumor necrosis factor is cytotoxic to human fibroblasts in the presence of exogenous arachidonic acid. | Arachidonic Acid | tumor necrosis factor | Homo sapiens |
| 2 | However, TNF had a cytotoxic effect upon the growth of FS-4 cells in combination with arachidonic acid. | Arachidonic Acid | tumor necrosis factor | Homo sapiens |
| 3 | Arachidonic acid inhibited the TNF-induced cell growth in a dose-dependent manner: it reversed the TNF-stimulated growth to the control level at a concentration of 10 microM and was cytotoxic to TNF-treated FS-4 cells at higher concentrations. | Arachidonic Acid | tumor necrosis factor | Homo sapiens |
| 4 | Arachidonic acid inhibited the TNF-induced cell growth in a dose-dependent manner: it reversed the TNF-stimulated growth to the control level at a concentration of 10 microM and was cytotoxic to TNF-treated FS-4 cells at higher concentrations. | Arachidonic Acid | tumor necrosis factor | Homo sapiens |
| 5 | Arachidonic acid inhibited the TNF-induced cell growth in a dose-dependent manner: it reversed the TNF-stimulated growth to the control level at a concentration of 10 microM and was cytotoxic to TNF-treated FS-4 cells at higher concentrations. | Arachidonic Acid | tumor necrosis factor | Homo sapiens |
| 6 | Indomethacin, a cyclooxygenase inhibitor, decreased the cytotoxic effect that TNF exerted in the presence of arachidonic acid. | Arachidonic Acid | tumor necrosis factor | Homo sapiens |
| 7 | These results suggest that TNF becomes cytotoxic to FS-4 cells when arachidonic acid present in the culture medium is converted to prostaglandins. | Arachidonic Acid | tumor necrosis factor | Homo sapiens |