Title : The tyrosine kinase Src promotes phosphorylation of the kinase TBK1 to facilitate type I interferon production after viral infection.

Pub. Date : 2017 Jan 3

PMID : 28049762






1 Functional Relationships(s)
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1 However, Src did not directly bind to recombinant TBK1 in vitro but instead bound to the proline-X-X-proline motifs within key PRR adaptor proteins, such as TRIF, MAVS, and STING, which formed complexes with TBK1 after PRR engagement. Proline SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens