Title : A semi-quantitative translational pharmacology analysis to understand the relationship between in vitro ENT1 inhibition and the clinical incidence of dyspnoea and bronchospasm.

Pub. Date : 2017 Feb 15

PMID : 28041785






1 Functional Relationships(s)
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1 For each patient population, the relationship between in vitro ENT1 [3H]-NBTI binding affinity (Ki) and [3H]-adenosine uptake (IC50) to the incidence of: (1) bronchospasm/severe dyspnoea; (2) tolerated dyspnoea and; (3) no adverse effects, was evaluated. Tritium solute carrier family 29 member 1 (Augustine blood group) Homo sapiens