Title : Use of non-selective β-blockers is associated with decreased tumor proliferative indices in early stage breast cancer.

Pub. Date : 2017 Jan 24

PMID : 28031536






1 Functional Relationships(s)
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1 Molecular analysis revealed that propranolol treatment of the SK-BR-3 breast cancer line, which showed high sensitivity to beta blockade, led to a reduction in Ki67 protein expression, decreased phosphorylation of the mitogenic signaling regulators p44/42 MAPK, p38 MAPK, JNK, and CREB, increased phosphorylation of the cell survival/apoptosis regulators AKT, p53, and GSK3beta. Propranolol AKT serine/threonine kinase 1 Homo sapiens