Title : Cell-based Fluorescence Complementation Reveals a Role for HIV-1 Nef Protein Dimerization in AP-2 Adaptor Recruitment and CD4 Co-receptor Down-regulation.

Pub. Date : 2017 Feb 17

PMID : 28031466






1 Functional Relationships(s)
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1 Mutagenesis of Nef amino acids Arg-134, Glu-174, and Asp-175, which stabilize Nef for AP-2 alpha-sigma2 binding in a recent co-crystal structure, substantially reduced AP-2 interaction without affecting CD4 binding. Glutamic Acid S100 calcium binding protein B Homo sapiens