Pub. Date : 2017 Feb
PMID : 28012930
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | While AA supplementation has been shown to attenuate HIF-1alpha function in malignant melanoma, the use of dehydroascorbic acid (DHA) as a therapeutic means to increase intracellular AA and modulate HIF-1alpha function is yet to be evaluated. | Dehydroascorbic Acid | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
2 | While AA supplementation has been shown to attenuate HIF-1alpha function in malignant melanoma, the use of dehydroascorbic acid (DHA) as a therapeutic means to increase intracellular AA and modulate HIF-1alpha function is yet to be evaluated. | Dehydroascorbic Acid | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
3 | Here we compared the ability of AA and DHA to increase intracellular vitamin C content and decrease the malignant potential of human melanoma by reducing the activity of HIF-1alpha. | Dehydroascorbic Acid | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
4 | While AA and A2P were capable of modulating HIF-1alpha protein accumulation/activity, DHA supplementation resulted in minimal intracellular vitamin C activity with decreased ability to inhibit HIF-1alpha activity and malignant potential in advanced melanoma. | Dehydroascorbic Acid | hypoxia inducible factor 1 subunit alpha | Homo sapiens |