Title : Ascorbic acid, but not dehydroascorbic acid increases intracellular vitamin C content to decrease Hypoxia Inducible Factor -1 alpha activity and reduce malignant potential in human melanoma.

Pub. Date : 2017 Feb

PMID : 28012930






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 While AA supplementation has been shown to attenuate HIF-1alpha function in malignant melanoma, the use of dehydroascorbic acid (DHA) as a therapeutic means to increase intracellular AA and modulate HIF-1alpha function is yet to be evaluated. Dehydroascorbic Acid hypoxia inducible factor 1 subunit alpha Homo sapiens
2 While AA supplementation has been shown to attenuate HIF-1alpha function in malignant melanoma, the use of dehydroascorbic acid (DHA) as a therapeutic means to increase intracellular AA and modulate HIF-1alpha function is yet to be evaluated. Dehydroascorbic Acid hypoxia inducible factor 1 subunit alpha Homo sapiens
3 Here we compared the ability of AA and DHA to increase intracellular vitamin C content and decrease the malignant potential of human melanoma by reducing the activity of HIF-1alpha. Dehydroascorbic Acid hypoxia inducible factor 1 subunit alpha Homo sapiens
4 While AA and A2P were capable of modulating HIF-1alpha protein accumulation/activity, DHA supplementation resulted in minimal intracellular vitamin C activity with decreased ability to inhibit HIF-1alpha activity and malignant potential in advanced melanoma. Dehydroascorbic Acid hypoxia inducible factor 1 subunit alpha Homo sapiens