Pub. Date : 2017 Mar
PMID : 28007926
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | BaP-induced Cyp1a1 and Cyp1b1 mRNA levels were higher 4 hours after dosing at noon than at 4 hours after dosing at midnight, and this corresponded with parallel changes in Per gene expression. | Benzo(a)pyrene | cytochrome P450, family 1, subfamily a, polypeptide 1 | Mus musculus |
| 2 | Analysis of CYP1A1 and CYP1B1 gene expression showed the maximum enzyme-induced metabolism response 12 and 20 hours after shock, as determined by ethoxyresorufin-O-deethylase activity, metabolism of BaP, and formation of DNA-BaP adducts. | Benzo(a)pyrene | cytochrome P450, family 1, subfamily a, polypeptide 1 | Mus musculus |
| 3 | Analysis of CYP1A1 and CYP1B1 gene expression showed the maximum enzyme-induced metabolism response 12 and 20 hours after shock, as determined by ethoxyresorufin-O-deethylase activity, metabolism of BaP, and formation of DNA-BaP adducts. | Benzo(a)pyrene | cytochrome P450, family 1, subfamily a, polypeptide 1 | Mus musculus |
| 4 | The pattern of PER-, BMAL-, and aryl hydrocarbon receptor-induced P450 gene expression and BaP metabolism was similar to BaP-induced Cyp1A1 and Cyp1B1 and molecular clock gene expression in mouse mammary glands. | Benzo(a)pyrene | cytochrome P450, family 1, subfamily a, polypeptide 1 | Mus musculus |