Title : The Neuroprotective Effect of Dimethyl Fumarate in an MPTP-Mouse Model of Parkinson's Disease: Involvement of Reactive Oxygen Species/Nuclear Factor-κB/Nuclear Transcription Factor Related to NF-E2.

Pub. Date : 2017 Sep 10

PMID : 28006954






4 Functional Relationships(s)
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1 Furthermore, DMF treatment upregulated the Nrf-2 pathway, increased NeuN+/Nrf-2+ cell number in the striatum, induced activation of manganese superoxide dismutase and heme oxygenase-1, and regulated glutathione levels. Dimethyl Fumarate NFE2 like bZIP transcription factor 2 Homo sapiens
2 Furthermore, DMF treatment upregulated the Nrf-2 pathway, increased NeuN+/Nrf-2+ cell number in the striatum, induced activation of manganese superoxide dismutase and heme oxygenase-1, and regulated glutathione levels. Dimethyl Fumarate NFE2 like bZIP transcription factor 2 Homo sapiens
3 The protective effects of DMF treatment, via Nrf-2, were confirmed in in vitro studies, through inhibition of Nrf-2 by trigonelline. Dimethyl Fumarate NFE2 like bZIP transcription factor 2 Homo sapiens
4 The protective effects of DMF treatment, via Nrf-2, were confirmed in in vitro studies, through inhibition of Nrf-2 by trigonelline. Dimethyl Fumarate NFE2 like bZIP transcription factor 2 Homo sapiens