Title : Model of the Interaction between the NF-κB Inhibitory Protein p100 and the E3 Ubiquitin Ligase β-TrCP based on NMR and Docking Experiments.

Pub. Date : 2017 Feb 27

PMID : 28004927






2 Functional Relationships(s)
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1 Four other arginines, Arg285, Arg410, Arg431, and Arg521, were found essential in the stabilization of p100 on the beta-TrCP surface. Arginine beta-transducin repeat containing E3 ubiquitin protein ligase Homo sapiens
2 Importantly, the requirement for these five arginine residues of beta-TrCP for the interaction with p100 was further confirmed in vivo, thereby validating the docking model through a biological approach. Arginine beta-transducin repeat containing E3 ubiquitin protein ligase Homo sapiens