Pub. Date : 2017 Jan 27
PMID : 28003362
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Phosphorylation of Rap1 by cAMP-dependent Protein Kinase (PKA) Creates a Binding Site for KSR to Sustain ERK Activation by cAMP. | Cyclic AMP | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | Phosphorylation of Rap1 by cAMP-dependent Protein Kinase (PKA) Creates a Binding Site for KSR to Sustain ERK Activation by cAMP. | Cyclic AMP | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | Cyclic adenosine monophosphate (cAMP) is an important mediator of hormonal stimulation of cell growth and differentiation through its activation of the extracellular signal-regulated kinase (ERK) cascade. | Cyclic AMP | mitogen-activated protein kinase 1 | Homo sapiens |
| 4 | Cyclic adenosine monophosphate (cAMP) is an important mediator of hormonal stimulation of cell growth and differentiation through its activation of the extracellular signal-regulated kinase (ERK) cascade. | Cyclic AMP | mitogen-activated protein kinase 1 | Homo sapiens |
| 5 | Cyclic adenosine monophosphate (cAMP) is an important mediator of hormonal stimulation of cell growth and differentiation through its activation of the extracellular signal-regulated kinase (ERK) cascade. | Cyclic AMP | mitogen-activated protein kinase 1 | Homo sapiens |
| 6 | Cyclic adenosine monophosphate (cAMP) is an important mediator of hormonal stimulation of cell growth and differentiation through its activation of the extracellular signal-regulated kinase (ERK) cascade. | Cyclic AMP | mitogen-activated protein kinase 1 | Homo sapiens |
| 7 | Using HEK293 cells as a model system, we have recently shown that both Ras and Rap1 are required for cAMP signaling to ERKs. | Cyclic AMP | mitogen-activated protein kinase 1 | Homo sapiens |
| 8 | However, cAMP-dependent Ras signaling to ERKs is transient and rapidly terminated by PKA phosphorylation of the Raf isoforms C-Raf and B-Raf. | Cyclic AMP | mitogen-activated protein kinase 1 | Homo sapiens |
| 9 | In contrast, cAMP-dependent Rap1 signaling to ERKs and Rap1 is potentiated by PKA. | Cyclic AMP | mitogen-activated protein kinase 1 | Homo sapiens |