Title : Phosphorylation of Rap1 by cAMP-dependent Protein Kinase (PKA) Creates a Binding Site for KSR to Sustain ERK Activation by cAMP.

Pub. Date : 2017 Jan 27

PMID : 28003362






9 Functional Relationships(s)
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Protein Name
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1 Phosphorylation of Rap1 by cAMP-dependent Protein Kinase (PKA) Creates a Binding Site for KSR to Sustain ERK Activation by cAMP. Cyclic AMP mitogen-activated protein kinase 1 Homo sapiens
2 Phosphorylation of Rap1 by cAMP-dependent Protein Kinase (PKA) Creates a Binding Site for KSR to Sustain ERK Activation by cAMP. Cyclic AMP mitogen-activated protein kinase 1 Homo sapiens
3 Cyclic adenosine monophosphate (cAMP) is an important mediator of hormonal stimulation of cell growth and differentiation through its activation of the extracellular signal-regulated kinase (ERK) cascade. Cyclic AMP mitogen-activated protein kinase 1 Homo sapiens
4 Cyclic adenosine monophosphate (cAMP) is an important mediator of hormonal stimulation of cell growth and differentiation through its activation of the extracellular signal-regulated kinase (ERK) cascade. Cyclic AMP mitogen-activated protein kinase 1 Homo sapiens
5 Cyclic adenosine monophosphate (cAMP) is an important mediator of hormonal stimulation of cell growth and differentiation through its activation of the extracellular signal-regulated kinase (ERK) cascade. Cyclic AMP mitogen-activated protein kinase 1 Homo sapiens
6 Cyclic adenosine monophosphate (cAMP) is an important mediator of hormonal stimulation of cell growth and differentiation through its activation of the extracellular signal-regulated kinase (ERK) cascade. Cyclic AMP mitogen-activated protein kinase 1 Homo sapiens
7 Using HEK293 cells as a model system, we have recently shown that both Ras and Rap1 are required for cAMP signaling to ERKs. Cyclic AMP mitogen-activated protein kinase 1 Homo sapiens
8 However, cAMP-dependent Ras signaling to ERKs is transient and rapidly terminated by PKA phosphorylation of the Raf isoforms C-Raf and B-Raf. Cyclic AMP mitogen-activated protein kinase 1 Homo sapiens
9 In contrast, cAMP-dependent Rap1 signaling to ERKs and Rap1 is potentiated by PKA. Cyclic AMP mitogen-activated protein kinase 1 Homo sapiens