Pub. Date : 2017 Mar 17
PMID : 27965414
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Surprisingly, we show that either PARP1 or PARP2 are sufficient for near-normal XRCC1 recruitment at oxidative single-strand breaks (SSBs) as indicated by the requirement for loss of both proteins to greatly reduce or ablate XRCC1 chromatin binding following H2O2 treatment. | Hydrogen Peroxide | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 2 | Notably, concentrations of PARP inhibitor >1000-fold higher than the IC50 were required to ablate both ADP-ribosylation and XRCC1 chromatin binding following H2O2 treatment. | Hydrogen Peroxide | poly(ADP-ribose) polymerase 1 | Homo sapiens |