Title : The Inflammation Induced by Lipopolysaccharide can be Mitigated by Short-chain Fatty Acid, Butyrate, through Upregulation of IL-10 in Septic Shock.

Pub. Date : 2017 Apr

PMID : 27943364






3 Functional Relationships(s)
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1 The Inflammation Induced by Lipopolysaccharide can be Mitigated by Short-chain Fatty Acid, Butyrate, through Upregulation of IL-10 in Septic Shock. Butyrates interleukin 10 Mus musculus
2 However, when detecting the anti-inflammatory factors, a significant increase in IL-10, but not TGF-beta or LXT4, was shown in butyrate-pretreated group. Butyrates interleukin 10 Mus musculus
3 Pretreatment of RAW 264.7 cells with butyrate led to downregulation of LPS-induced pro-inflammatory mediators, IL-6 and IL-1beta, but did not affect the level of TNF-alpha, and increased IL-10 (P < 0.01). Butyrates interleukin 10 Mus musculus