Title : Testosterone supplementation improves glucose homeostasis despite increasing hepatic insulin resistance in male mouse model of type 2 diabetes mellitus.

Pub. Date : 2016 Dec 12

PMID : 27941939






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1 However, testosterone treatment inactivated GSK3alpha independent of PI3K/AKT pathway and inhibited FOXO1 By interaction of androgen receptor to FOXO1 and downregulated PEPCK, causing repression of gluconeogenic pathway, which is otherwise upregulated in T2DM, resulted in better glucose homeostasis. Testosterone thymoma viral proto-oncogene 1 Mus musculus