Pub. Date : 2016 Dec
PMID : 27941164
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Single nucleotide polymorphisms of IFNgamma (+874 A/T) and IFNgammaR1 (-56 C/T) in Iranian patients with TB. | Terbium | interferon gamma receptor 1 | Homo sapiens |
| 2 | Allele T frequencies of IFNgammaR1 -56 C/T promoter region in patients with pulmonary TB (PTB) or extrapulmonary TB (EPTB) were significantly greater than allele C. The -56 TT motif of IFNgammaR1 is associated with both forms of TB (p<0.05). | Terbium | interferon gamma receptor 1 | Homo sapiens |
| 3 | Allele T frequencies of IFNgammaR1 -56 C/T promoter region in patients with pulmonary TB (PTB) or extrapulmonary TB (EPTB) were significantly greater than allele C. The -56 TT motif of IFNgammaR1 is associated with both forms of TB (p<0.05). | Terbium | interferon gamma receptor 1 | Homo sapiens |
| 4 | Allele T frequencies of IFNgammaR1 -56 C/T promoter region in patients with pulmonary TB (PTB) or extrapulmonary TB (EPTB) were significantly greater than allele C. The -56 TT motif of IFNgammaR1 is associated with both forms of TB (p<0.05). | Terbium | interferon gamma receptor 1 | Homo sapiens |
| 5 | Allele T frequencies of IFNgammaR1 -56 C/T promoter region in patients with pulmonary TB (PTB) or extrapulmonary TB (EPTB) were significantly greater than allele C. The -56 TT motif of IFNgammaR1 is associated with both forms of TB (p<0.05). | Terbium | interferon gamma receptor 1 | Homo sapiens |
| 6 | CONCLUSIONS: The cause of active TB in the patients seems to be due to the lack of effective IFNgamma function or the lack of effective signaling connection between IFNgamma and its receptor in presence of -56 C/T polymorphism in promoter region of IFNgammaR1 gene. | Terbium | interferon gamma receptor 1 | Homo sapiens |