Title : Discovery of Leucyladenylate Sulfamates as Novel Leucyl-tRNA Synthetase (LRS)-Targeted Mammalian Target of Rapamycin Complex 1 (mTORC1) Inhibitors.

Pub. Date : 2016 Nov 23

PMID : 27933890






1 Functional Relationships(s)
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1 Recent studies indicate that LRS may act as a leucine sensor for the mTORC1 pathway, potentially providing an alternative strategy to overcome rapamycin resistance in cancer treatments. Leucine leucyl-tRNA synthetase 1 Homo sapiens