Title : Functional characterization of rare FOXP2 variants in neurodevelopmental disorder.

Pub. Date : 2016

PMID : 27933109






2 Functional Relationships(s)
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1 Finally, we analysed the functional significance of the polyglutamine tracts in FOXP2, since tract length variations have been reported in cases of neurodevelopmental disorder. polyglutamine forkhead box P2 Homo sapiens
2 Finally, we found that FOXP2 variants with reduced polyglutamine tracts did not exhibit altered behaviour in cellular assays, indicating that such tracts are non-essential for core aspects of FOXP2 function, and that tract variation is unlikely to be a highly penetrant cause of speech/language disorder. polyglutamine forkhead box P2 Homo sapiens