Pub. Date : 2017 Oct
PMID : 27931982
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | However, tofacitinib robustly inhibited the production of IFNalpha by toll like receptor-stimulated PDC. | tofacitinib | interferon alpha 1 | Homo sapiens |
| 2 | In addition, tofacitinib profoundly suppressed IFNalpha-induced upregulation of TLR3 on synovial fibroblasts, thereby inhibiting their cytokine and protease production in response to TLR3 ligation. | tofacitinib | interferon alpha 1 | Homo sapiens |
| 3 | Finally, tofacitinib counteracted the suppressive effects of IFNalpha on viral replication. | tofacitinib | interferon alpha 1 | Homo sapiens |
| 4 | Tofacitinib inhibits PDC survival and IFNalpha production and suppresses arthrogenic and antiviral effects of IFNalpha signaling. | tofacitinib | interferon alpha 1 | Homo sapiens |
| 5 | Tofacitinib inhibits PDC survival and IFNalpha production and suppresses arthrogenic and antiviral effects of IFNalpha signaling. | tofacitinib | interferon alpha 1 | Homo sapiens |
| 6 | Inhibition of the IFNalpha pathway at 2 levels may contribute to the beneficial effects of tofacitinib in autoimmune diseases and explain the increased viral infection rates observed during tofacitinib treatment. | tofacitinib | interferon alpha 1 | Homo sapiens |
| 7 | Inhibition of the IFNalpha pathway at 2 levels may contribute to the beneficial effects of tofacitinib in autoimmune diseases and explain the increased viral infection rates observed during tofacitinib treatment. | tofacitinib | interferon alpha 1 | Homo sapiens |