Pub. Date : 2017 Aug 1
PMID : 27927016
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of Cathepsin S Induces Mitochondrial ROS That Sensitizes TRAIL-Mediated Apoptosis Through p53-Mediated Downregulation of Bcl-2 and c-FLIP. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 2 | Interestingly, ZFL induced p53 expression via production of mitochondrial reactive oxygen species (ROS). | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 3 | Interestingly, ZFL induced p53 expression via production of mitochondrial reactive oxygen species (ROS). | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 4 | CONCLUSION: Our results indicated that inhibition of cathepsin S stimulates TRAIL-induced apoptosis through downregulation of Bcl-2 and Cbl-mediated c-FLIP by ROS-mediated p53 expression. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |