Title : Selective Enhancement of Insulin Sensitivity in the Endothelium In Vivo Reveals a Novel Proatherosclerotic Signaling Loop.

Pub. Date : 2017 Mar 3

PMID : 27920123






4 Functional Relationships(s)
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1 Insulin-stimulated phosphorylation of protein kinase B was increased in hIRECO EC as was Nox2 NADPH oxidase-dependent generation of superoxide, whereas insulin-stimulated and shear stress-stimulated eNOS activations were blunted. Superoxides insulin Homo sapiens
2 CONCLUSIONS: Enhancing insulin sensitivity specifically in EC leads to a paradoxical decline in endothelial function, mediated by increased tyrosine phosphorylation of eNOS and excess Nox2-derived superoxide. Superoxides insulin Homo sapiens
3 Increased EC insulin sensitivity leads to a proatherosclerotic imbalance between NO and superoxide. Superoxides insulin Homo sapiens
4 This study demonstrates for the first time that increased endothelial insulin sensitivity leads to a proatherosclerotic imbalance between NO and superoxide. Superoxides insulin Homo sapiens