Title : The reduced concentration of citrate in cancer cells: An indicator of cancer aggressiveness and a possible therapeutic target.

Pub. Date : 2016 Nov

PMID : 27912843






1 Functional Relationships(s)
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1 Strategies aiming to increase cytosolic citrate should be developed and tested in humans, knowing that experimental studies have shown that administration of citrate and/or inhibition of ACLY arrest tumor growth, inhibit the expression of the key anti-apoptotic factor Mcl-1, reverse cell dedifferentiation and increase sensibility to cisplatin. Citric Acid ATP citrate lyase Homo sapiens