Pub. Date : 2016
PMID : 27904766
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The role of PIM1 in the ibrutinib-resistant ABC subtype of diffuse large B-cell lymphoma. | ibrutinib | ATP binding cassette subfamily B member 6 (Langereis blood group) | Homo sapiens |
| 2 | A phase 1/2 clinical trial of single-agent ibrutinib in relapsed and refractory DLBCL patients revealed an overall response rate of 37% in ABC-DLBCL patients. | ibrutinib | ATP binding cassette subfamily B member 6 (Langereis blood group) | Homo sapiens |
| 3 | Here we report the discovery of point mutations within the kinase PIM1 that reduce sensitivity to ibrutinib in ABC-DLBCL. | ibrutinib | ATP binding cassette subfamily B member 6 (Langereis blood group) | Homo sapiens |
| 4 | The introduction of mutant PIM1 into an ABC-DLBCL cell line, TMD8, increased colony formation and decreased sensitivity to ibrutinib. | ibrutinib | ATP binding cassette subfamily B member 6 (Langereis blood group) | Homo sapiens |