Title : P2Y6 Receptor Antagonist MRS2578 Inhibits Neutrophil Activation and Aggregated Neutrophil Extracellular Trap Formation Induced by Gout-Associated Monosodium Urate Crystals.

Pub. Date : 2017 Jan 1

PMID : 27903742






1 Functional Relationships(s)
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1 Our results indicate that the P2Y6/store-operated calcium entry/IL-8 axis is involved in MSU crystal-induced aggregated NET formation, but MRS2578 could have additional effects affecting PMN migration. Calcium C-X-C motif chemokine ligand 8 Homo sapiens