Title : Homology modeling and molecular dynamics simulation of the HIF2α degradation-related HIF2α-VHL complex.

Pub. Date : 2017 Jan

PMID : 27902963






1 Functional Relationships(s)
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1 Under normoxic conditions, a conserved proline in HIF2alpha is hydroxylated by PHD2 in an oxygen-dependent manner, and then pVHL binds and promotes the degradation of HIF2alpha. Proline von Hippel-Lindau tumor suppressor Homo sapiens