Title : Elucidating the Plasma and Liver Pharmacokinetics of Simeprevir in Special Populations Using Physiologically Based Pharmacokinetic Modelling.

Pub. Date : 2017 Jul

PMID : 27896690






2 Functional Relationships(s)
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1 The disposition of simeprevir (SMV) in humans is characterised by cytochrome P450 3A4 metabolism and hepatic uptake by organic anion transporting polypeptide 1B1/3 (OATP1B1/3). Simeprevir cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 The disposition of simeprevir (SMV) in humans is characterised by cytochrome P450 3A4 metabolism and hepatic uptake by organic anion transporting polypeptide 1B1/3 (OATP1B1/3). Simeprevir cytochrome P450 family 3 subfamily A member 4 Homo sapiens