Pub. Date : 2016
PMID : 27895927
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The genetic mutation is an expansion of CAG trinucleotide repeats within the coding region of the ataxin-1 gene, characterizing SCA1 as a polyglutamine expansion disease like Huntington"s. | polyglutamine | ataxin 1 | Homo sapiens |
| 2 | The genetic mutation is an expansion of CAG trinucleotide repeats within the coding region of the ataxin-1 gene, characterizing SCA1 as a polyglutamine expansion disease like Huntington"s. | polyglutamine | ataxin 1 | Homo sapiens |
| 3 | As with most polyglutamine expansion diseases, SCA1 follows the rules of genetic anticipation: the larger the expansion, the earlier and more rapid the symptoms. | polyglutamine | ataxin 1 | Homo sapiens |
| 4 | Unlike the majority of polyglutamine expansion diseases, the presence of histidine interruptions within the polyglutamine tract of ataxin-1 protein can prevent or mitigate disease. | polyglutamine | ataxin 1 | Homo sapiens |
| 5 | Unlike the majority of polyglutamine expansion diseases, the presence of histidine interruptions within the polyglutamine tract of ataxin-1 protein can prevent or mitigate disease. | polyglutamine | ataxin 1 | Homo sapiens |
| 6 | The present review aims to synthesize three decades of research on the ataxin-1 polyglutamine expansion mutation that causes SCA1. | polyglutamine | ataxin 1 | Homo sapiens |
| 7 | The present review aims to synthesize three decades of research on the ataxin-1 polyglutamine expansion mutation that causes SCA1. | polyglutamine | ataxin 1 | Homo sapiens |