Title : Aberrant base excision repair pathway of oxidatively damaged DNA: Implications for degenerative diseases.

Pub. Date : 2017 Jun

PMID : 27890638






2 Functional Relationships(s)
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1 Importantly, in DNA repair deficient cells bacterial MutY, human TDG and mammalian MMR can act in the aberrant manner: MutY and TDG removes adenine and thymine opposite misincorporated 8-oxoguanine and damaged adenine, respectively, whereas MMR removes thymine opposite to O6-methylguanine. 8-hydroxyguanine thymine DNA glycosylase Homo sapiens
2 Importantly, in DNA repair deficient cells bacterial MutY, human TDG and mammalian MMR can act in the aberrant manner: MutY and TDG removes adenine and thymine opposite misincorporated 8-oxoguanine and damaged adenine, respectively, whereas MMR removes thymine opposite to O6-methylguanine. 8-hydroxyguanine thymine DNA glycosylase Homo sapiens