Pub. Date : 1989 Aug 15
PMID : 2788162
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Deuterium isotope effect measurements on the interactions of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine with monoamine oxidase B. | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | monoamine oxidase B | Homo sapiens |
| 2 | Kinetic deuterium isotope effects for the noncompetitive, intermolecular monoamine oxidase B-catalyzed oxidation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to the corresponding 1-methyl-4-phenyl-2,3-dihydropyridinium species MPDP+ were found to be 3.55 on Vmax and 8.01 on Vmax/Km with MPTP-6,6-d2 as the deuterated substrate. | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | monoamine oxidase B | Homo sapiens |
| 3 | Kinetic deuterium isotope effects for the noncompetitive, intermolecular monoamine oxidase B-catalyzed oxidation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to the corresponding 1-methyl-4-phenyl-2,3-dihydropyridinium species MPDP+ were found to be 3.55 on Vmax and 8.01 on Vmax/Km with MPTP-6,6-d2 as the deuterated substrate. | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | monoamine oxidase B | Homo sapiens |
| 4 | Isotope effect measurements also established that the rate of inactivation of monoamine oxidase B by MPTP is unaffected by replacement of the C-6 methylene protons with deuterons, but is retarded by replacement of the C-2 methylene protons (DKi = 1.9). | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | monoamine oxidase B | Homo sapiens |
| 5 | The mechanism-based inactivation of monoamine oxidase B by MPTP, therefore, is likely to mediated by a species derived from the enzyme-generated 2,3-dihydropyridinium oxidation product. | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | monoamine oxidase B | Homo sapiens |